Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system
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چکیده
منابع مشابه
Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system.
Wiring of the nervous system is a multi-step process involving complex interactions of the growing fibre with its tissue environment and with neighbouring fibres. Nogo-A is a membrane protein enriched in the adult central nervous system (CNS) myelin, where it restricts the capacity of axons to grow and regenerate after injury. During development, Nogo-A is also expressed by neurons but its func...
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Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER) resident protein with neuroprotective effects. Previous studies have shown that MANF expression is altered in the developing rodent cortex in a spatiotemporal manner. However, the role of MANF in mammalian neurogenesis is not known. The aim of this study was to determine the role of MANF in neural stem c...
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OF THE DISSERTATION ........................................................................... ii Acknowledgements ............................................................................................................ iv List of Tables ................................................................................................................... viii List of illustrations ..............
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PURPOSE To investigate the in vitro effect of short interfering RNAs (siRNAs) against Nogo receptor (NgR) on neurite outgrowth under an inhibitory substrate of central nervous system (CNS) myelin. METHODS Three siRNA sequences against NgR were designed and transfected into cerebellar granule cells (CGCs) to screen for the most effcient sequence of NgR siRNA by using reverse transcription poly...
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ژورنال
عنوان ژورنال: Development
سال: 2010
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.048371